Admittingly, I was first hesitant to write about psychedelics. For better of worse, these substances have become associated with the anti-establishment and counterculture movements of the 1960’s. Consequently, psychedelics carry a lot of stereotypes and cultural baggage from the past. Nonetheless, after reading Michael Pollan’s fantastic book, How to Change Your Mind and looking into additional research I became convinced of the potential of psychedelics to bring about transformative experiences. If used under the guidance and supervision of trained medical professionals, psychedelics have been shown to have significant positive effects in mental healthcare.
Psychedelics which include substances such as DMT, LSD and psilocybin (magic mushrooms) produce altered states of consciousness resulting in temporary changes to cognition. At a rudimentary level, psychedelics appear affect the brain’s serotonin system, fostering new neural pathways in the brain.
You may still be wondering, how one experiencing these peculiar and strange altered states of consciousness can have lasting effects on one’s perspective of the world, and effectively address a range of mental health issues.
One of the leading theories that seeks to explain how psychedelics affect the brain is Robin Carhart-Harris’ Entropic Brain Hypothesis. The theory develops a model in which different states of consciousness are ordered based on their level of entropy, or rigidity they encompass.
Many mental illnesses including depression, post-traumatic stress disorder, obsessions and eating disorders are characterized by inflexible thought patterns and fixed narratives we develop based on how we conceptualize the world. These illnesses narrow of perspectives, in which we become terrorized by our own destructive ‘egos’. Our incessant fears or past traumas become filters to how we shape our lives and view reality.
On the other end of the spectrum are high entropic states of consciousness which are embodied by chaos. These states are characterized by disorder and flexibility. Examples of high entropy mental states include infant consciousness, sensory depravation and psychedelic states. A basic diagram depicting this model can be seen below.
Psychedelics are particularly useful for individuals with on the ‘low entropy’ side of the spectrum. They help disrupt negative patterns of thought which have become ingrained in our minds by introducing more flexibility – more entropy. Observed by scientists, when an individual is on psilocyn “thousands of new connections form, linking far-flung brain regions that during normal waking consciousness don’t exchange much information.” A visual representation of the difference between a placebo (image A) versus a brain on psilocyn (image B) can be seen below.
A hallmark of the psychedelic experience is ‘ego dissolution’, the disappearance of our sense of ‘self’, and a feeling of ‘oneness’ with the universe. Michael Pollan describes his experience with ‘ego dissolution’ on psilocybin
The sovereign ego, with all its armaments and fears, its backward-looking resentments and forward-looking worries, was simply no more. Yet something had succeeded it: this bare disembodied awareness, which gazed upon the scene of the self’s dissolution with benign indifference. I was present to reality but as something other than my self. And although there was no self left to feel, exactly, there was a feeling tone, which was calm, unburdened, content.
From a neuroscience lens, psychedelics decrease activity in the default-mode network which is considered to be region of the brain which is synonymous with ‘the self’ or what we call ‘I’. When activity in the default mode network falls off, the ego disappears temporarily liberating us from the excessive and unproductive ruminations of the mind. When this occurs, we can rid ourselves of destructive stories and ideas we hold dear, and have the opportunity to craft new narratives.
Psychedelics may be a shortcut to achieving what long experienced meditators have been training years to attain, the relief from what Buddhists call the ‘monkey mind’ or the ‘no-self.’ In this state we are liberated from attachment, and the separation between subject and object disappears. At a minimum, psychedelics show us that there exist many different forms of consciousness and unique perceptions of reality that we can experience throughout our lives. This offers us a unique opportunity to view the world from a different lens.
To quote William James in his book The Varieties of Religious Experience,
Our normal waking consciousness, rational consciousness as we call it, is but one special type of consciousness, whilst all about it, parted from it by the filmiest of screens, there lie potential forms of consciousness entirely different. We may go through life without suspecting their existence; but apply the requisite stimulus, and at a touch they are there in all their completeness
These are no doubt powerful substances which if used in the wrong context can have negative repercussions both on an individual and societal level. Nonetheless, if used in as a medicine rather than as a recreational drug in a safe and regulated environment, psychedelics can perhaps give us a momentary glimpse of enlightenment.
Next time I’ll explore in more detail what the clinical trials are revealing about the therapeutic use of psychedelics in mental health care.
Till next time,